Chapter

Advanced Issues in Meta-Analysis

Diana B. Petitti

in Meta-Analysis, Decision Analysis, and Cost-Effectiveness Analysis

Second edition

Published in print November 1999 | ISBN: 9780195133646
Published online September 2009 | e-ISBN: 9780199863761 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195133646.003.06

Series: Monographs in Epidemiology and Biostatistics

Advanced Issues in Meta-Analysis

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This chapter is the first of three chapters in this book that describes methods that apply only to systematic review and meta-analysis. It first discusses the goals, timing, and process of defining the eligibility of studies for the systematic review/meta-analysis and the rationale for these basic eligibility criteria. It then explains how to choose an estimate of effect from studies with more than one estimate is described. The final section discusses how to rate study quality and how information on study quality can be used in a systematic review. Since 2000, the consensus about methods to rate study quality and the use of the ratings of quality has evolved. Available in 2009 are widely accepted checklists/rating scales to assess the quality of randomized clinical trials (CONSORT) and epidemiologic studies (QUORM). The last section of this is obsolete except in its critique of the use of quality rating as a weighting variable in meta-analysis.

Keywords: systematic review; CONSORT; QUORUM; quality rating

Chapter.  7996 words.  Illustrated.

Subjects: Public Health and Epidemiology

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