Chapter

Genetic Epidemiology of Neurologic Disease

Lorene M. Nelson, Caroline M. Tanner, Stephen K. Van Den Eeden and Valerie M. McGuire

in Neuroepidemiology

Published in print January 2004 | ISBN: 9780195133790
Published online September 2009 | e-ISBN: 9780199863730 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195133790.003.04
Genetic Epidemiology of Neurologic Disease

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This chapter begins with a discussion of Mendelian versus complex (non-Mendelian) neurological disorders, followed by an overview of the structure of DNA and the molecular basis of disease. It considers the methods of genetic epidemiology, differentiating family-based studies from population-based studies of unaffected individuals. The options for genetic epidemiology study designs are presented, with a discussion of strengths and limitations of each approach. Recent technological developments are discussed, as are the important ethical and social implications of genetic epidemiologic research in the study of neurological disorders.

Keywords: genetic epidemiology; Hardy-Weinberg equilibrium; Mendelian disorders; molecular epidemiology; family-based studies; population-based studies; ethical issues; social issues

Chapter.  8846 words.  Illustrated.

Subjects: Public Health and Epidemiology

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