Chapter

Neurochemical Modulation of Prefrontal Cortical Function in Humans and Animals

Amy F.T. Arnsten and Trevor W. Robbins

in Principles of Frontal Lobe Function

Published in print August 2002 | ISBN: 9780195134971
Published online May 2009 | e-ISBN: 9780199864157 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195134971.003.0004
Neurochemical Modulation of Prefrontal Cortical Function in Humans and Animals

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The cognitive functions of the prefrontal cortex (PFC), which include use of working memory to guide behavioral responses and the contents of attentional focus, the inhibition of inappropriate responses, and planning for the future, are among the most fragile in the behavioral repertoire. Deficits in PFC function are evident in every neuropsychiatric disorder. The abilities carried out by the PFC can also become impaired in so-called “normal” individuals under conditions of uncontrollable stress, fatigue, and with advancing age. This chapter reviews research from both animal and human studies on the ways in which dopamine (DA), norepinephrine (NE), serotonin (5HT), and acetylcholine (ACh) may modulate PFC cognitive functions.

Keywords: prefrontal cortex; cognitive function; dopamine; norepinephrine; serotonin; acetylcholine

Chapter.  21872 words.  Illustrated.

Subjects: Neuroscience

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