Chapter

Chemical Transmission at Synapses (1945–1965)

Joseph D. Robinson

in Mechanisms of Synaptic Transmission

Published in print June 2001 | ISBN: 9780195137613
Published online March 2012 | e-ISBN: 9780199848164 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195137613.003.0004
Chemical Transmission at Synapses (1945–1965)

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This chapter discusses advances in identifying chemical transmission across synapses from 1945 to 1965. John C. Eccles dominated synaptic physiology before this period, first defending electrical transmission energetically and then demonstrating chemical transmission decisively. During these two decades, new experimental techniques, notably those exploiting intracellular microelectrodes and electron microscopes, extended the principle of chemical transmission from the autonomic nervous system to neuromuscular junctions and the central nervous system. New general phenomena were recognized, such as presynaptic inhibition, and new circuits for reciprocal control were delineated.

Keywords: chemical transmission; synapses; Eccles; electrical transmission; autonomic nervous system; neuromuscular junctions; central nervous system; presynaptic inhibition; reciprocal control

Chapter.  10741 words.  Illustrated.

Subjects: Neuroscience

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