Identifying Neurotransmitters (1946–1976)

Joseph D. Robinson

in Mechanisms of Synaptic Transmission

Published in print June 2001 | ISBN: 9780195137613
Published online March 2012 | e-ISBN: 9780199848164 | DOI:
Identifying Neurotransmitters (1946–1976)

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This chapter describes further experiments in identifying neurotransmitters in the central nervous system. After decades of concentration on acetylcholine and adrenaline/noradrenaline, new studies shifted the focus. Glutamate turned out to be the major excitatory neurotransmitter in the brain as well as the sensory neurotransmitter of dorsal root ganglion cells. GABA turned out to be the major inhibitory neurotransmitter in the brain, with glycine a prominent inhibitory neurotransmitter in the spinal cord. Furthermore, considerations of pathologies and therapeutics fostered an interest in many of the more newly established neurotransmitters, notably dopamine, serotonin, GABA, and enkephalin.

Keywords: neurotransmitters; central nervous system; glutamate; GABA; glycine; dopamine; serotonin; enkephalin

Chapter.  9069 words.  Illustrated.

Subjects: Neuroscience

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