Chapter

Introduction: Relating Disease to Exposure

Thomas J. Smith and David Kriebel

in A Biologic Approach to Environmental Assessment and Epidemiology

Published in print August 2010 | ISBN: 9780195141566
Published online January 2011 | e-ISBN: 9780199872145 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195141566.003.0001
Introduction: Relating Disease to Exposure

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The goal of environmental health is the prevention of disease through identification and elimination of environmental hazards or the reduction of exposures. This chapter argues that although exposure assessment and epidemiology can contribute to continued progress in achieving this goal, it will not occur without integrated, biologically based methods of study design and analysis. With the rapid proliferation of molecular and cell biology, the mechanisms underlying pathologic processes leading to adverse effects are increasingly well understood. This new knowledge should be used more systematically as the theoretical basis of exposure-response modeling. Disease process models can provide a simple but useful starting point and a framework for added complexity as new information is discovered.

Keywords: black box epidemiology; epidemiologic investigations; disease exposure; exposure response modelling; disease process models

Chapter.  7923 words.  Illustrated.

Subjects: Public Health and Epidemiology

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