Chapter

Reversible Proportional Disease Processes: Effects of Ammonia and Ozone on Respiratory Symptoms

Thomas J. Smith and David Kriebel

in A Biologic Approach to Environmental Assessment and Epidemiology

Published in print August 2010 | ISBN: 9780195141566
Published online January 2011 | e-ISBN: 9780199872145 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195141566.003.0011
Reversible Proportional Disease Processes: Effects of Ammonia and Ozone on Respiratory Symptoms

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This chapter illustrates the modeling of reversible proportional disease processes using two examples. It first continues to use the simple case of ammonia leading to eye irritation that was presented in Chapters 6 and 10. Then, a more complex case is explored: the respiratory effects of ozone. A historical perspective on ozone dose-response modeling is useful because the literature followed a path of increasingly complex and biologically relevant models as more and more data were obtained. Laying out this history illustrates the limitations of the empirical approach and the advantages of biologically based models.

Keywords: exposure assessment; epidemiologic study; ammonia; respiratory effects; ozone; dose-response modeling

Chapter.  10819 words.  Illustrated.

Subjects: Public Health and Epidemiology

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