Chapter

Reversible Discrete Disease Processes: Asthma and Indoor Air, Dermatitis and Metalworking Fluids

Thomas J. Smith and David Kriebel

in A Biologic Approach to Environmental Assessment and Epidemiology

Published in print August 2010 | ISBN: 9780195141566
Published online January 2011 | e-ISBN: 9780199872145 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195141566.003.0014
Reversible Discrete Disease Processes: Asthma and Indoor Air, Dermatitis and Metalworking Fluids

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This chapter illustrates the application of the disease process model approach to discrete reversible disease processes. The process model approach is applied in five steps: (1) identifying and showing the relevance of a tentative process model; (2) identifying one or more markers of the key effect; (3) choosing an etiologic time interval; (4) selecting the hypothetical agent(s) and a measurable marker for exposure; and (5) defining a summary dose metric that represents our hypothesis about the agent and mechanism to be tested in an epidemiologic study.

Keywords: disease process model; asthma; air pollution; dermatitis; machining fluid exposure; epidemiologic studies

Chapter.  8088 words.  Illustrated.

Subjects: Public Health and Epidemiology

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