Chapter

Survival Analysis Cox’s Proportional Hazards Model)

Steve Selvin

in Epidemiologic Analysis

Published in print August 2001 | ISBN: 9780195146189
Published online September 2009 | e-ISBN: 9780199864720 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195146189.003.0013
Survival Analysis Cox’s Proportional Hazards Model)

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This chapter examines the prognostic roles in the development of acquired immune deficiency syndrome (AIDS) of two indicators of infection (CD4 lymphocyte counts and β2-microglobulin levels) in human immunodeficiency virus (HIV)-positive men when these values are recorded at the initial HIV diagnosis. When HIV-positive individuals have initial CD4 counts above 400, the risk of AIDS is substantially less than that of individuals with CD4 counts below 400. The estimated rates of conversion are: for CD4 < 400, the rate is 0.033 (95% CI: 0.021, 0.081); for 400 < CD4 < 900, the rate is 0.008 (95% CI: 0.006, 0.012); and for CD4 > 900 the rate is 0.007 (95% CI: 0.004, 0.025). A graphic analysis supports the conjecture that the hazard functions within each of these three groups are approximately constant.

Keywords: HIV; CD4; AIDS; lymphocytes; microglobulin

Chapter.  5408 words.  Illustrated.

Subjects: Public Health and Epidemiology

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