Chapter

Molecular and Genetic Events in Neoplastic Transformation

AYSE E. ERSON and ELIZABETH M. PETTY

in Cancer Epidemiology and Prevention

Third edition

Published in print October 2006 | ISBN: 9780195149616
Published online September 2009 | e-ISBN: 9780199865062 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195149616.003.0004
Molecular and Genetic Events in Neoplastic Transformation

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This chapter illustrates some of the basic molecular and genetic mechanisms that underlie the development of cancer. The chapter is organized into four main sections. The first section examines perspectives on the roles of oncogenes, tumor suppressor genes, and genomic instability genes in the pathogenesis of malignancy. The second section presents the genetic and epigenetic alterations that disrupt normal function of cancer genes. The third section discusses the alteration of cell cycle progression and checkpoint mechanisms relative to their possible contribution to carcinogenesis. The last section summarizes the phenotypic characteristics of cancer cells, including proliferation, apoptosis, angiogenesis, and metastasis as related to specific molecular events.

Keywords: cancer development; cancer genes; cancer cells; oncogenes; tumor suppressor genes; genomic instability; malignancy

Chapter.  16388 words.  Illustrated.

Subjects: Public Health and Epidemiology

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