Chapter

The Leukemias

MARTHA S. LINET, SUSAN S. DEVESA and GARETH J. MORGAN

in Cancer Epidemiology and Prevention

Third edition

Published in print October 2006 | ISBN: 9780195149616
Published online September 2009 | e-ISBN: 9780199865062 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195149616.003.0044
The Leukemias

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The leukemias arise from malignant transformation of hematopoietic stem or progenitor cells that originate in the bone marrow, lymph nodes, and/or other lymphoid tissue with immune function. A small pool of stem cells, which persists throughout an individual's lifetime, differentiates to early precursors, then divides into multiple subtypes, and ultimately produces large numbers of end-stage cells of myeloid and lymphoid lineage progeny. Because the effector or end-stage cells of each lineage have a finite lifespan and, therefore, cannot transmit mutations, all leukemias are the consequence of derangements of growth and differentiation of the pluripotential early precursors of myeloid or lymphoid progeny. This chapter discusses the epidemiology of the myeloid and lymphoid leukemias.

Keywords: myeloid leukemia; lymphoid leukemia; cancer risk; cancer epidemiology; cancer prevention; lympth nodes

Chapter.  35872 words.  Illustrated.

Subjects: Public Health and Epidemiology

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