Chapter

Cytokine and Chemokine Receptors and Signaling

Duane R. Wesemann and Etty N. Benveniste

in Neuroglia

Published on behalf of Oxford University Press

Published in print October 2004 | ISBN: 9780195152227
Published online September 2013 | e-ISBN: 9780199865024 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195152227.003.0011
                      Cytokine and Chemokine Receptors and Signaling

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This chapter discusses the activation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway and the mechanisms that are used to control the magnitude and duration of signaling. It focuses on the suppressor of cytokine signaling (SOCS) family of proteins that act in a negative feedback loop to extinguish signal transduction. It also briefly reviews the other major signalling pathways that are used by tumor necrosis factor (TNF) family members and members of the transforming growth factor (TGF) family. In addition, signaling by chemokines through G-protein-coupled chemokine receptors is described.

Keywords: Janus kinase; signal transducers; activators; cytokine signaling; chemokine receptor; tumor necrosis factor

Chapter.  9713 words.  Illustrated.

Subjects: Neuroscience

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