Second Messenger Systems

Sean Murphy and Brian R. Pearce

in Neuroglia

Published on behalf of Oxford University Press

Published in print October 2004 | ISBN: 9780195152227
Published online September 2013 | e-ISBN: 9780199865024 | DOI:
                      Second Messenger Systems

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This chapter focuses on recent developments in (predominantly astro-) glial second messenger pathways, particularly those involved in intracellular Ca2+ signaling. It illustrates signaling cascades in glia by reference to the regulation of expression and activity of the nitric oxide synthases (NOS). The product of NOS activity, nitric oxide (NO), then interacts with numerous other molecules, including cyclooxygenase (COX)-2. The chapter draws attention to the evidence for assemblies of signaling molecules. Compared with highly polarized endothelial cells and neurons, little attention has been paid to such compartmentation within glia.

Keywords: glial cells; second messenger pathways; intracellular signaling; nitric oxide synthase; cyclooxygenase

Chapter.  10167 words.  Illustrated.

Subjects: Neuroscience

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