Intracellular Calcium Control Mechanisms in Glia

Maria Luisa Cotrina and Maiken Nedergaard

in Neuroglia

Published on behalf of Oxford University Press

Published in print October 2004 | ISBN: 9780195152227
Published online September 2013 | e-ISBN: 9780199865024 | DOI:
                      Intracellular Calcium Control Mechanisms in Glia

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Glial cells rely on calcium ions to display a large variety of signaling capabilities inside the cell and among neighboring cells. These calcium activities are key to regulating not only the growth and survival of glial cells but also the communication with neurons. As glial cells are not electrically excitable, calcium signaling, specially in astrocytes, is particularly important to understand how glia regulate synaptic activity and brain function. This chapter discusses evidence for the existence of calcium signaling in glia, the different mechanisms of glial calcium signaling, its spatial and temporal resolution, and how glial cells make use of this diverse array of activities to modulate neuronal function.

Keywords: glial cells; calcium signaling; neuronal function; synaptic activity; spatial resolution; temporal resolution

Chapter.  6259 words.  Illustrated.

Subjects: Neuroscience

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