Cytoskeletal Proteins in Astroglia

Lawrence F. Eng and Yuen Ling Lee

in Neuroglia

Published on behalf of Oxford University Press

Published in print October 2004 | ISBN: 9780195152227
Published online September 2013 | e-ISBN: 9780199865024 | DOI:
                      Cytoskeletal Proteins in Astroglia

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The cytoskeleton is essential for many cellular processes, including mechanical strength, movement, adhesion, polarity, and intracellular trafficking. The cytoplasm of animal cells is structured by scaffolding composed of actin filaments (microfilaments), microtubules, and intermediate filaments (IFs) all joined by cross-linking proteins such as plakins. This chapter focuses on the intermediate filament (IF) protein in astroglia. Glial fibrillary acidic protein is the IF protein found in differentiated astrocytes in the central nervous system (CNS). Rapid advances in molecular biology and newer techniques such as knockout mice, the use of the gfa-2 promoter to prepare transgenes, antisense RNA methodology, and DNA sequencing have greatly increased our knowledge of GFAP function in CNS development, injury, and disease.

Keywords: glial cells; intermediate filaments; cytoskeleton; glial fibrillary acidic protein; astrocyte

Chapter.  8185 words.  Illustrated.

Subjects: Neuroscience

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