Chapter

Antigen Processing, Presentation, and T Cell Interaction

Harald Neumann

in Neuroglia

Published on behalf of Oxford University Press

Published in print October 2004 | ISBN: 9780195152227
Published online September 2013 | e-ISBN: 9780199865024 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195152227.003.0024
                      Antigen Processing, Presentation, and T Cell Interaction

Show Summary Details

Preview

This chapter discusses antigen processing, presentation, and T cell interaction. The central nervous system (CNS) is protected by a blood-brain barrier (BBB) designed to minimize the passage of immune cells and macromolecules into the brain parenchyma. In the normal CNS parenchyma antigen-presenting cells (APCs) are functionally inactivated and lack expression of major histocompatibility complex (MHC) molecules. Nevertheless, the CNS is routinely surveyed by activated T lymphocytes. Perivascular macrophages situated adjacent to the endothelium cells of the blood vessels take up and present antigens to T lymphocytes. Most cells of the brain parenchyma are immunologically quiescent in the healthy CNS, but can be stimulated to become facultative APCs that process and present antigens via their MHC molecules to T lymphocytes in neuroinflammatory diseases.

Keywords: central nervous system; blood-brain barrier; antigen-presenting cells; major histocompatibility complex; endothelium cells

Chapter.  8507 words.  Illustrated.

Subjects: Neuroscience

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.