Astrocyte Neurotransmitter Uptake

Raymond A. Swanson

in Neuroglia

Published on behalf of Oxford University Press

Published in print October 2004 | ISBN: 9780195152227
Published online September 2013 | e-ISBN: 9780199865024 | DOI:
                      Astrocyte Neurotransmitter Uptake

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The action of neurotransmitters can be terminated by cleavage, diffusion, binding, or cellular uptake. In some cases, uptake is accomplished by glial cells localized at or near the synapse. Glial cells express a variety of neurotransmitter uptake systems, and these systems play a fundamental role in both normal brain function and disease states. All types of glial cells—astrocytes, oligodendrocytes, and microglia—can express transporters for neurotransmitter uptake. This chapter focuses on astrocyte glutamate uptake, which is the most fully characterized of the astrocyte neurotransmitter uptake systems.

Keywords: astrocytes; neurotransmitter uptake systems; astrocyte glutamate; glial cells

Chapter.  6271 words.  Illustrated.

Subjects: Neuroscience

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