The Central Role of Astrocytes in Neuroenergetics

Luc Pellerin and Pierre J. Magistretti

in Neuroglia

Published on behalf of Oxford University Press

Published in print October 2004 | ISBN: 9780195152227
Published online September 2013 | e-ISBN: 9780199865024 | DOI:
                      The Central Role of Astrocytes in Neuroenergetics

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This chapter reviews astrocyte function in the maintenance metabolic homeostasis. Astrocytes play essential roles in coupling neuronal activity to energy metabolism, both through their participation in the glutamate/glutamine cycle and by providing lactate to neurons as an additional energy substrate in register with increased activity. It also appears that astrocytes participate in coupling neuronal activity to blood flow. Such findings are important not only for the understanding of fundamental aspects of brain functions, but also for the use of functional brain imaging techniques that rely on metabolic and vascular parameters to map cognitive processes.

Keywords: astrocyte; neurons; metabolic homeostasis; glutamate; glutamine cycle

Chapter.  8050 words.  Illustrated.

Subjects: Neuroscience

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