Growth Factors for Neurons Provided by Macroglial Cells

Bernhard Reuss and Klaus Unsicker

in Neuroglia

Published on behalf of Oxford University Press

Published in print October 2004 | ISBN: 9780195152227
Published online September 2013 | e-ISBN: 9780199865024 | DOI:
                      Growth Factors for Neurons Provided by Macroglial Cells

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Neuronal survival and functions require bidirectional communication between neurons and glia that involves a large variety of growth factors. Neurotrophic factors are operationally defined as proteins that regulate neuron survival and differentiation. They can be synthesized by nonneuronal target cells, neurons, and glial cells. This chapter focuses on neurotrophic factors secreted from macroglial cells, that is, astrocytes, oligodendrocytes, and Schwann cells, and their effects on neuronal differentiation and survival in the intact and lesioned brain and peripheral nervous system.

Keywords: neurotrophic factors; macroglial cells; astrocytes; oligodendrocytes; Schwann cells; glial cells

Chapter.  9112 words.  Illustrated.

Subjects: Neuroscience

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