Chapter

Response of Microglia to Brain Injury

Kazuyuki Nakajima and Shinichi Kohsaka

in Neuroglia

Published on behalf of Oxford University Press

Published in print October 2004 | ISBN: 9780195152227
Published online September 2013 | e-ISBN: 9780199865024 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195152227.003.0035
                      Response of Microglia to Brain Injury

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This chapter discusses the response of microglia to brain injuries. Microglia are activated to induce various cellular changes, including morphology, immunohistochemical properties, proliferative activity, chemotactic mobility, biochemical change, secretion, and phagocytosis, in response to the signal(s) produced in the extracellular milieu of the pathological brain. Some putative or plausible signals from injured neurons or activated astrocytes have been predicted based on an acute injury model. In response to these candidate molecules, the microglia produce a specific combination of secretory molecules through a specific signal transduction cascade. Thus, the activated microglia might play different roles according to the type of pathology.

Keywords: microglial activation; glial cells; brain injuries; astrocytes; cellular changes

Chapter.  7416 words.  Illustrated.

Subjects: Neuroscience

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