Human Immunodeficiency Virus Infection of the Central Nervous System

Elena Ryzhova, Dennis L. Kolson and Francisco González-Scarano

in Neuroglia

Published on behalf of Oxford University Press

Published in print October 2004 | ISBN: 9780195152227
Published online September 2013 | e-ISBN: 9780199865024 | DOI:
                      Human Immunodeficiency Virus Infection of the Central Nervous System

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A significant proportion of individuals with human immunodeficiency virus (HIV) infection develop a neurological syndrome consisting of psychomotor retardation, dementia, and associated findings that was initially termed the acquired immunodeficiency syndrome (AIDS) dementia complex. This syndrome is now commonly known as HIV-associated dementia (HAD). This chapter discusses the clinical and pathological features, and pathophysiology in HIV-associated dementia, and the role of microglia in mediating neuronal injury in HIV infection.

Keywords: HIV-associated dementia; AIDS; microglia; neuronal injury; brain macrophages

Chapter.  7284 words.  Illustrated.

Subjects: Neuroscience

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