Chapter

Neurological Mouse Mutants: A Molecular-Genetic Analysis of Myelin Proteins

Klaus-Armin Nave and Ueli Suter

in Neuroglia

Published on behalf of Oxford University Press

Published in print October 2004 | ISBN: 9780195152227
Published online September 2013 | e-ISBN: 9780199865024 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195152227.003.0043
                      Neurological Mouse Mutants: A Molecular-Genetic Analysis of Myelin Proteins

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This chapter presents an overview of mutations in the mouse that have improved our understanding of structural myelin proteins. Mouse genetics, in combination with molecular cell biology and morphology, has provide important insights into the process of myelination. For some myelin proteins, a specific function in the architecture of myelin can be demonstrated. In other cases, a more complex picture has emerged from overlapping loss-of-function and aberrant gain-of-function effects. The latter is a recurrent feature of natural point mutations with autosomal dominant (or X-linked recessive) inheritance.

Keywords: mutations; myelin; myelination; mouse models

Chapter.  13233 words.  Illustrated.

Subjects: Neuroscience

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