Chapter

The Role of Longitudinal Studies in the Early Detection of Dementia

K. Warner Schaie

in Developmental Influences on Adult Intelligence

Published in print February 2005 | ISBN: 9780195156737
Published online September 2007 | e-ISBN: 9780199786817 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195156737.003.0017
 The Role of Longitudinal Studies in the Early Detection of Dementia

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Although the Seattle Longitudinal Study was designed to focus on cognitive changes in normal community-dwelling populations, it is inevitable that a prospective study of aging will eventually include in its successive follow-up cycles individuals who are beginning to show cognitive impairment and eventually may develop full-blown symptoms of dementia. This chapter reports some initial findings on the apolipoprotein E genetic marker of dementia as it relates to cognitive decline. Studies involving the neuropsychological assessment of a community-dwelling sample of older adults who have not previously been identified as suffering from cognitive impairment are described, along with the extension analyses that link the clinical measures with the psychometric battery for the study of normal aging. The chapter ends by analyzing studies that obtain postdicted estimates of earlier performance on the neuropsychological measures and speak to the possibility of early detection of risk for cognitive impairment.

Keywords: Seattle Longitudinal Study; longitudinal studies; dementia; apolipoprotein E; genetic markers; cognitive impairment

Chapter.  8144 words. 

Subjects: Developmental Psychology

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