Role of Dopamine Systems in Cognitive Aging

Lars Bäckman and Lars Farde

in Cognitive Neuroscience of Aging

Published in print December 2004 | ISBN: 9780195156744
Published online May 2009 | e-ISBN: 9780199864171 | DOI:
 							Role of Dopamine Systems in Cognitive Aging

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This chapter reviews literature on the influence of age-related changes in the nigrostriatal dopamine (DA) system on age-related cognitive changes. The chapter is organized as follows: first, it provides an empirical and theoretical rationale for the cognitive relevance of DA. This is followed by an overview of the organization of DA systems in the brain. It describes the basic principles for imaging of the DA system then discusses evidence for an influence of adult age on various DA markers. The major findings in behavioral research on cognitive aging are reviewed. The sections converge into a review of research examining the correlative triad among age, DA markers, and cognitive performance. The findings from this research are then positioned in relation to other theory and data in the cognitive neuroscience of aging. The chapter concludes by suggesting avenues for future empirical research on DA functions and cognitive aging.

Keywords: age-related cognitive changes; dopamine systems; brain imaging; cognitive performance; nigrostriatal dopamine system; DA markers

Chapter.  13497 words.  Illustrated.

Subjects: Neuroscience

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