Chapter

Orienting and Placing

Tim Schallert and Martin T. Woodlee

in The Behavior of the Laboratory Rat

Published in print September 2004 | ISBN: 9780195162851
Published online May 2009 | e-ISBN: 9780199863891 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195162851.003.0012
 Orienting and Placing

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This chapter describes behavioral tests that have been useful for examining the potential clinical efficacy of interventions that might be beneficial for neurological disorders. It is important to distinguish whether an intervention promotes brain repair mechanisms, saves cells, enhances motor learning and retraining, or reduces the extent of secondary degeneration of tissue. The chapter includes a subset of sensorimotor tests that are considered to be reliable, sensitive, quantitative, and easy to use in rat neurological models. The tests also cover the range of cellular degeneration typical of focal ischemic injury, nigrostriatal terminal loss, and cervical spinal trauma.

Keywords: laboratory rats; behavioral tests; neurological disorders; sensorimotor tests; focal ischemic injury; nigrostriatal terminal loss; cervical spinal trauma

Chapter.  6013 words.  Illustrated.

Subjects: Neuroscience

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