Chapter

Subjective Effects of Opioids

Sandy M. Comer and James P. Zacny

in Mind-Altering Drugs

Published in print May 2005 | ISBN: 9780195165319
Published online April 2010 | e-ISBN: 9780199894055 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195165319.003.0008
Subjective Effects of Opioids

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Opioids, which have long been abused, are capable of producing euphoria and other “positive” subjective effects. Although the relationship between positive subjective effects and abuse of a drug is not necessarily causal, there is a predictive relationship between those drugs that produce a positive spectrum of subjective effects and their likelihood of functioning as reinforcers and being abused. A host of factors influence the subjective effects of opioids (and subsequently their abuse liability); some of the more salient ones are covered in this chapter. It first describes how subjective effects of opioids are measured and then discusses how such factors as dose, route of administration, rate of onset of drug effects, tolerance and dependence, and drug use history can all influence an opioid's subjective effects.

Keywords: opioids; drug abuse; subjective effects; drug use

Chapter.  10020 words. 

Subjects: Clinical Pharmacology and Therapeutics

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