Relationships Between Personality and Acute Subjective Responses to Stimulant Drugs

Harriet De Wit

in Mind-Altering Drugs

Published in print May 2005 | ISBN: 9780195165319
Published online April 2010 | e-ISBN: 9780199894055 | DOI:
Relationships Between Personality and Acute Subjective Responses to Stimulant Drugs

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This chapter reviews recent studies that have examined the relationship between personality and the quality and magnitude of mood changes after acute administration of stimulant drugs, with a view to investigating the existence of common underlying brain processes. There is some evidence that the trait of extraversion/sensation seeking may be related to activating and positive affective responses to stimulant drugs, whereas the trait of neuroticism/negative emotionality may be related to dysphoric responses to these drugs. Further, there is some evidence that both extraversion and positive responses to drugs may be related to dopamine function. However, the neurochemical basis of either the trait of neuroticism or the dysphoric responses to stimulant drugs remains unknown, although they may involve either of the other two primary neurotransmitters involved in stimulant effects, norepinephrine or serotonin. Little remains known about how personality or its neurobiological underpinnings affect acute subjective responses to drugs.

Keywords: drug use; personality; mood changes; stimulants; subjective effects

Chapter.  7625 words. 

Subjects: Clinical Pharmacology and Therapeutics

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