Brain Serotonin and Aggressive Disposition in Humans and Nonhuman Primates

Stephen B. Manuck, Jay R. Kaplan and Francis E. Lotrich

in Biology of Aggression

Published in print September 2005 | ISBN: 9780195168761
Published online May 2009 | e-ISBN: 9780199865444 | DOI:
 							Brain Serotonin and Aggressive Disposition in Humans and Nonhuman Primates

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This chapter begins with a brief introduction to the neurobiology of serotonin, including common methods of investigation and sources of serotonin-associated genetic variation. It briefly addresses comparative conceptualizations of aggressive behavior in nonhuman primates and people, including the role of antagonistic interaction in primate social dominance and human psychopathology. It summarizes the substantial literature on CNS serotonergic activity as a correlate of aggressive disposition, as seen in studies employing neurochemical indices of serotonergic function, neuropharmacologic challenges, functional neuroimaging, and neurogenetic methodologies. Finally, the chapter attempts to integrate observations derived from studies on monkeys and humans, identify implications of these findings for models of serotonergic influences on aggression, and speculate briefly regarding possible evolutionary origins of these associations.

Keywords: neurochemistry; aggression; serotonergic activity; primates; neuroimaging; antagonistic interaction

Chapter.  35150 words. 

Subjects: Neuroscience

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