Chapter

Dopaminergic Modulation of Cognition in Human Aging

Shu-Chen Li, Ulman Lindenberger, Lars Nyberg, Hauke R. Heekeren and Lars Bäckman

in Imaging the Aging Brain

Published in print October 2009 | ISBN: 9780195328875
Published online February 2010 | e-ISBN: 9780199864836 | DOI: https://dx.doi.org/10.1093/acprof:oso/9780195328875.003.0005
Dopaminergic Modulation of Cognition in Human Aging

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This chapter reviews evidence from recent studies applying a wide range of imaging methods and computational approaches to investigate age-related neurochemical changes that affect neuronal signal transduction. Specifically, we focus on age-related impairments in the dopamine (DA) systems and their relations to cognitive deficits in late life. Other neurotransmitter systems—most notably acetylcholine, norepinephrine, serotonin, and glutamate—also undergo alterations during the adult life course. Thus far, however, the DA systems have attracted most attention and there is mounting evidence that DA is a key neurotransmitter in the context of cognitive aging. Molecular imaging methods for assessing age-related decline in pre- and post-synaptic markers of the dopaminergic systems as well as more recent genomic imaging, multimodal imaging, and computational neuroscience approaches to investigate how dopaminergic modulation affects cognitive aging are particularly highlighted.

Keywords: cognition; aging; dopamine; genes; receptor imaging; genomic imaging; multimodal imaging; serotonin; norepinephrine

Chapter.  16719 words.  Illustrated.

Subjects: Neuroscience

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