Chapter

Functional Heterogeneity in Striatal Subregions and Neurotransmitter Systems: Implications for Understanding the Neural Substrates Underlying Appetitive Motivation and Learning

Brian A. Baldo and Matthew E. Andrzejewski

in Dopamine Handbook

Published in print October 2009 | ISBN: 9780195373035
Published online February 2010 | e-ISBN: 9780199865543 | DOI: https://dx.doi.org/10.1093/acprof:oso/9780195373035.003.0021
Functional Heterogeneity in Striatal Subregions and Neurotransmitter Systems: Implications for Understanding the Neural Substrates Underlying Appetitive Motivation and Learning

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This chapter focuses on how advances in the study of striatal anatomy and physiology have informed our appreciation of dopamine's role in appetitive motivation, with an emphasis on studies of feeding behavior, food-reinforced operant behavior, and striatal gene expression, under different motivational conditions. It outlines the position that striatal dopamine plays a dual role in augmenting the various types of motor output associated with appetitively motivated behavior, by modulating information flow through functionally differentiable corticostriatal circuits, and in selecting/strengthening reinforced behavior by regulating intracellular plasticity within a corticostriatal network. Evidence indicates that while these functions are expressed throughout the striatum, the behavioral domains that are affected depend upon the unique information-processing roles of anatomically distinct striatal territories. Finally, the chapter discusses the additional layer of complexity conferred by the heterogeneous functions of discrete neurochemical systems within a given striatal territory.

Keywords: striatum; dopamine; appetitive motivation; feeding behavior; striatal gene expression; food reinforced operant behavior

Chapter.  11313 words.  Illustrated.

Subjects: Neuroscience

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