Fallible Design: Protein-Coding DNA Sequences

John C. Avise

in Inside the Human Genome

Published in print February 2010 | ISBN: 9780195393439
Published online May 2010 | e-ISBN: 9780199775415 | DOI:
Fallible Design: Protein-Coding DNA Sequences

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This chapter addresses the history and current state of knowledge about human inborn errors of metabolism. Mutations in protein‐coding genes slaughter or maim countless individuals (especially embryos and fetuses) and promote legions of genetic disabilities in our species. Included in this chapter are empirical examples from the many thousands of known instances in which standard “good‐housekeeping” genes occasionally go bad, via deleterious mutations, and thereby contribute to the morbid anatomy of the human genome. Collectively, humanity bears a heavy genetic load from these genetic disorders, a fact that poses profound interpretive challenges for both science and religion.

Keywords: mutations; genetic load; genetic disorders; proteins; metabolism

Chapter.  9390 words.  Illustrated.

Subjects: Evolutionary Biology

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