Dopaminergic Imaging in Parkinson’s Disease: PET

Biju Gopalakrishnan and A. Jon Stoessl

in Imaging in Parkinson’s Disease

Published in print September 2011 | ISBN: 9780195393484
Published online September 2011 | e-ISBN: 9780199914494 | DOI:
Dopaminergic Imaging in Parkinson’s Disease: PET

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Positron emission tomography (PET) is a functional imaging technique utilized in Parkinson’s disease (PD) largely to assess the integrity of the nigrostriatal dopamine system. This chapter reviews the methodological aspects of dopaminergic PET imaging particularly involving specific radiotracer approaches to quantify pre- and postsynaptic function in health and disease. Also discussed are applications of dopaminergic PET for differential diagnosis, evaluation of non-motor disease manifestations, and the objective measurement of disease progression in clinical and genetic disease subtypes. The potential limitations of this imaging approach are also addressed.

Keywords: Parkinson’s disease; positron emission tomography; dopamine; functional imaging; disease progression; differential diagnosis

Chapter.  6379 words.  Illustrated.

Subjects: Neuroscience

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