Dopaminergic Imaging in Parkinson’s Disease: SPECT

Christoph Scherfler and Werner Poewe

in Imaging in Parkinson’s Disease

Published in print September 2011 | ISBN: 9780195393484
Published online September 2011 | e-ISBN: 9780199914494 | DOI:
Dopaminergic Imaging in Parkinson’s Disease: SPECT

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The diagnosis of idiopathic Parkinson’s disease (PD) can often be made on clinical grounds with a high degree of accuracy particularly in cases with full expression of the classical motor features of the illness. Nonetheless, considerable diagnostic uncertainty can exist at early disease stages, particularly when clinical signs are subtle or equivocal. This chapter focuses on methodological aspects of dopamine transporter (DAT) SPECT, its role in assessing PD progression, and its potential use in the diagnosis of atypical parkinsonism. The chapter also examines the application of this tool to the study of clinically relevant pathologies such as psychogenic, vascular and drug-induced parkinsonism, dementia with Lewy bodies, and essential tremor. The chapter also addresses the potential of DAT-SPECT to identify subjects at risk for PD will be discussed.

Keywords: dopamine transporter; single photon emission computed tomography; atypical parkinsonism; drug-induced parkinsonism; Parkinson’s disease progression; at-risk subjects

Chapter.  7292 words.  Illustrated.

Subjects: Neuroscience

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