Chapter

Structural Abnormalities in Parkinson’s Disease

Kathrin Reetz and Ferdinand Binkofski

in Imaging in Parkinson’s Disease

Published in print September 2011 | ISBN: 9780195393484
Published online September 2011 | e-ISBN: 9780199914494 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195393484.003.0027
Structural Abnormalities in Parkinson’s Disease

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The traditional role of MRI in parkinsonism is to exclude secondary causes of symptoms. Recent advances in MR methodology, including voxel-based morphometry, diffusion imaging, and inversion recovery sequences, have yielded new tools for the detection of nigral and extra-nigral pathology in PD. These advanced anatomical and functional MR techniques have substantially improved the accuracy of differential diagnosis and contributed to the understanding of the pathophysiology of the parkinsonian disorders. In this chapter, the authors provide a comprehensive review of MR applications for the study of PD. They also include interesting material on the use of these approaches in the assessment of cognitive and affective disease manifestations in PD patients and the evaluation of individuals with disease-related genetic mutations.

Keywords: Parkinson’s disease; voxel-based morphometry; diffusion-tensor MR; cognitive impairment; Parkinson’s disease dementia; PD-related genetic mutations

Chapter.  13751 words.  Illustrated.

Subjects: Neuroscience

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