Chapter

Brain Activation Studies in Parkinson’s Disease

L. K. Prashanth and Antonio P. Strafella

in Imaging in Parkinson’s Disease

Published in print September 2011 | ISBN: 9780195393484
Published online September 2011 | e-ISBN: 9780199914494 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195393484.003.0060
Brain Activation Studies in Parkinson’s Disease

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This chapter provides an overview of brain activation studies of the pathophysiology of the motor, cognitive, and behavioral symptoms of Parkinson’s disease (PD). Discussion focuses on activation studies using PET and fMRI in association with on-line recordings of task performance, as well as concurrent neurostimulation techniques such as deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS). This line of experimentation has contributed greatly to current knowledge of the distributed neural systems that mediate the motor and cognitive/affective manifestations of the disease. The chapter demonstrates how mapping brain regions with abnormal neural activation responses can inform the search for new therapeutic targets for PD and related disorders.

Keywords: Parkinson’s disease; brain activation; fMRI; PET; motor and cognitive performance

Chapter.  7630 words.  Illustrated.

Subjects: Neuroscience

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