Chapter

Imaging Inflammation in Parkinsonian Syndromes

David J. Brooks

in Imaging in Parkinson’s Disease

Published in print September 2011 | ISBN: 9780195393484
Published online September 2011 | e-ISBN: 9780199914494 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195393484.003.0089
Imaging Inflammation in Parkinsonian Syndromes

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In vivo markers of microglial activation such as 11C-PK11195 PET can provide a measure of ongoing neurodegeneration in patients with PD and other parkinsonian syndromes. The spatial distribution of microglial activation revealed by PET studies using this approach is concordant with known patterns of histopathological change involving the substantia nigra, striatum and nucleus basalis, and in the cingulate and temporal cortex of non-demented patients. The chapter reviews how these findings are substantiated in vivo with 11C-PK11195 PET, pointing to widespread brain involvement early in the clinical course of the disease. The chapter also discusses the potential impact of neuroimaging investigations on the role of microglial activation in PD on drug development, as well as applications to the pathophysiology of PD and atypical forms of parkinsonism.

Keywords: microglial activation; neuroinflammation; PET; PD; atypical parkinsonism

Chapter.  4076 words.  Illustrated.

Subjects: Neuroscience

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