Chapter

Functional Imaging Biomarkers for the Assessment of Parkinson’s Disease Progression

Chris C. Tang and David Eidelberg

in Imaging in Parkinson’s Disease

Published in print September 2011 | ISBN: 9780195393484
Published online September 2011 | e-ISBN: 9780199914494 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195393484.003.0093
Functional Imaging Biomarkers for the Assessment of Parkinson’s Disease Progression

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A reasonable degree of symptom relief can be achieved in most PD patients, particularly at early disease stages. Nonetheless, despite symptomatic treatment, the disease process continues, with the ultimate development of substantial functional disability and increasing socioeconomic burden. In recent years, clinical trials have focused on the development of therapies designed to retard disease progression of PD. To evaluate these interventions, a number of imaging strategies have been developed for the objective assessment of disease progression in treated and control populations. This chapter reviews these approaches, particularly those involving the imaging of nigrostriatal presynaptic dopaminergic function as well as regional brain metabolism. Of interest is a discussion of the use of metabolic networks as imaging biomarkers for the objective assessment of rates of progression at the systems level.

Keywords: biomarkers; Parkinson’s disease; brain metabolism; PET; metabolic networks; disease progression

Chapter.  7298 words.  Illustrated.

Subjects: Neuroscience

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