Chapter

Effects of Treatment

Alain Dagher

in Imaging in Parkinson’s Disease

Published in print September 2011 | ISBN: 9780195393484
Published online September 2011 | e-ISBN: 9780199914494 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195393484.003.0100
Effects of Treatment

Show Summary Details

Preview

Pharmacological therapy to augment dopamine neurotransmission, either with levodopa or a dopamine agonist, relieves the motor deficits of Parkinson’s disease (PD) consistently and rapidly. However, PD is also associated with cognitive and emotional disturbances, whose response to dopamine therapy is inconsistent or, in some cases, deleterious. While the neurochemical mechanism of action of levodopa or dopamine agonists is straightforward, the effects of these medications on the neural systems mediating motor and cognitive task performance can be assessed in detail using functional neuroimaging. This chapter reviews the literature on the use of PET and fMRI to study these important, clinically relevant treatment effects. Detailed discussion is provided concerning the neural substrates underlying the cognitive and behavioral effects of treatment.

Keywords: levodopa; dopamine agonists; PET; fMRI; cognitive performance; Parkinson’s disease (PD)

Chapter.  9520 words.  Illustrated.

Subjects: Neuroscience

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.