Effects of Treatment

Alain Dagher

in Imaging in Parkinson’s Disease

Published in print September 2011 | ISBN: 9780195393484
Published online September 2011 | e-ISBN: 9780199914494 | DOI:
Effects of Treatment

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Pharmacological therapy to augment dopamine neurotransmission, either with levodopa or a dopamine agonist, relieves the motor deficits of Parkinson’s disease (PD) consistently and rapidly. However, PD is also associated with cognitive and emotional disturbances, whose response to dopamine therapy is inconsistent or, in some cases, deleterious. While the neurochemical mechanism of action of levodopa or dopamine agonists is straightforward, the effects of these medications on the neural systems mediating motor and cognitive task performance can be assessed in detail using functional neuroimaging. This chapter reviews the literature on the use of PET and fMRI to study these important, clinically relevant treatment effects. Detailed discussion is provided concerning the neural substrates underlying the cognitive and behavioral effects of treatment.

Keywords: levodopa; dopamine agonists; PET; fMRI; cognitive performance; Parkinson’s disease (PD)

Chapter.  9520 words.  Illustrated.

Subjects: Neuroscience

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