Chapter

Neuroimaging in Levodopa-Induced Dyskinesia

Shigeki Hirano

in Imaging in Parkinson’s Disease

Published in print September 2011 | ISBN: 9780195393484
Published online September 2011 | e-ISBN: 9780199914494 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195393484.003.0105
Neuroimaging in Levodopa-Induced Dyskinesia

Show Summary Details

Preview

The pathophysiology of levodopa-induced dyskinesias (LID) is complex and cannot be explained by a single factor. PET imaging has provided novel insights into the understanding of this common side effect of dopaminergic therapy. In this chapter, functional imaging studies of LID are reviewed with a detailed summary of investigations of the relationship between LID and abnormalities in dopaminergic functioning, as well as changes in other neurochemical pathways. Recent studies linking LID to chronic changes in vascular microstructure and alterations in the normal neuro-vascular couple are also discussed.

Keywords: Parkinson’s disease; levodopa-induced dyskinesia; dopaminergic therapy; PET; neuro-vascular couple

Chapter.  5962 words.  Illustrated.

Subjects: Neuroscience

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.