Chapter

Effects of Surgical Treatment

Anna L. Bartels and Klaus L. Leenders

in Imaging in Parkinson’s Disease

Published in print September 2011 | ISBN: 9780195393484
Published online September 2011 | e-ISBN: 9780199914494 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195393484.003.0109
Effects of Surgical Treatment

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This chapter summarizes the contribution of imaging to the current understanding of the mechanisms underlying surgical interventions for PD. Structural imaging studies using MRI techniques have served to improve the accuracy of stereotaxic targeting. That said, functional imaging with positron emission tomography (PET), single photon emission tomography (SPECT), and fMRI have provided an in vivo method to assess changes in brain function in the vicinity of the surgical target and in remote, interconnected brain regions within a spatially distributed neural network. This chapter provides an overview of functional/anatomical models of basal ganglia circuitry, followed by a discussion of the changes mediated by surgery at both the regional and network levels. Specific attention is dedicated to the effects of deep brain stimulation (DBS) on network organization and on disease progression.

Keywords: Parkinson’s disease; basal ganglia circuitry; PET; fMRI; SPECT; deep brain stimulation; disease progression

Chapter.  6194 words.  Illustrated.

Subjects: Neuroscience

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