Chapter

Cell-Based Therapies

Paola Piccini and Marios Politis

in Imaging in Parkinson’s Disease

Published in print September 2011 | ISBN: 9780195393484
Published online September 2011 | e-ISBN: 9780199914494 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195393484.003.0114
Cell-Based Therapies

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This chapter discusses recent advances in the field of cell therapy for Parkinson’s disease and the utilization of functional imaging to monitor survival and growth of grafted human embryonic dopamine cells. Additionally, studies of long-term treatment outcome are reviewed, including the potential application of preoperative imaging for the selection of transplantation candidates. The chapter also provides valuable new data on imaging changes underlying complications of therapy such as graft-related dyskinesias. Additional data are provided on the use of novel PET tracers to assess the role of serotonergic terminals in grafted tissue as well as MRI methods to evaluate changes in neural circuitry following cell implantation.

Keywords: Parkinson’s disease; cell transplantation; embryonic dopamine cells; PET; MRI; clinical outcome; graft-related dyskinesias

Chapter.  5939 words.  Illustrated.

Subjects: Neuroscience

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