Personalized Medicine for Schizophrenia

Jacob S. Ballon, Ragy R. Girgis and Jeffrey A. Lieberman

in Integrative Neuroscience and Personalized Medicine

Published in print December 2010 | ISBN: 9780195393804
Published online January 2011 | e-ISBN: 9780199863495 | DOI:
Personalized Medicine for Schizophrenia

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This chapter discusses the potential for personalized medicine as it applies to schizophrenia, one of the most severe mental disorders. The first half of this chapter will address the genetics of schizophrenia, and in particular what is known about the pharmacogenomics of treatment response and side effects. The second half will focus on the neurobiology and physical abnormalities of schizophrenia, and discuss these in the context of endophenotypes and biomarkers of the illness. Finally, this chapter will conclude with a synthesis of the previously discussed genetic and neurobiological findings in schizophrenia and ideas on how this knowledge can be translated into the framework of personalized medicine.

Keywords: personalized medicine; schizophrenia; pharmacogenomics; neurobiology; endophenotypes; biomarkers

Chapter.  14407 words. 

Subjects: Neuroscience

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