Bertil Hille

Larry R. Squire

in The History of Neuroscience in Autobiography

Seventh edition

Published in print September 2011 | ISBN: 9780195396133
Published online January 2012 | e-ISBN: 9780199918409 | DOI:
Bertil Hille

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Bertil Hille helped establish the concept of ion channels as membrane proteins forming gated aqueous pores. He showed that Na+ and K+ channels of axons can be distinguished by drugs such as tetrodotoxin and tetraethyl ammonium ion, and that their ionic selectivity can be understood by a limiting pore size, the selectivity filter, and by movements of ions through a series of saturable sites. He showed that local anesthetics enter Na+ channels in a state-dependent manner. In later studies of modulation of ion channels by G-protein coupled receptors he distinguished two new signaling pathways. A fast, pertussis toxin sensitive pathway turned on inward rectifier K+ channels and turned off Ca2+ channels by G protein G(( subunits. A slow, pertussis toxin insensitive pathway turned off some K+ and Ca2+ channels by depleting the plasma membrane phosphoinositide PIP2. Hille wrote the widely used textbook, Ion Channels of Excitable Membranes.

Keywords: ion channels; member proteins; Na+ channels; G-protein coupled receptors; signaling pathways

Chapter.  22455 words. 

Subjects: Neuroscience

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