Chapter

Krešimir Krnjevic´

Larry R. Squire

in The History of Neuroscience in Autobiography

Seventh edition

Published in print September 2011 | ISBN: 9780195396133
Published online January 2012 | e-ISBN: 9780199918409 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195396133.003.0007
Krešimir Krnjevic´

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Krešimir Krnjević contributed to the identification of main neurotransmitters in the mammalian brain, notably the previously unsuspected transmitter functions of some amino acids – especially glutamate for excitation and GABA for inhibition; also the slower, muscarinic excitation - shown to be mediated by reduction in K conductance – exerted by acetylcholine and liberated in the cortex by ascending cholinergic fibres from the basal forebrain; as well as the opposite hyperpolarizing action of cytoplasmic Ca ions. These were viewed as possible mechanisms of consciousness and anaesthesia.

Keywords: neurotransmitters; amino acids; glutamate; GABA; acetylcholine; anesthesia

Chapter.  25131 words. 

Subjects: Neuroscience

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