Chapter

Design and analysis issues in genome-wide association studies

Duncan C. Thomas

in Human Genome Epidemiology, 2nd Edition

Published in print December 2009 | ISBN: 9780195398441
Published online May 2010 | e-ISBN: 9780199776023 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195398441.003.0008
 							Design and analysis issues in genome-wide association studies

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The recent availability of commercial high-density genotyping technologies, combined with the identification of subsets of single nucleotide polymorphisms (SNPs) that are capable of “tagging” most of the common variants in the human genome from the HapMap project, has now made it feasible to conduct genome-wide association studies (GWAS). There have now been quite a few reviews of the general principles of the design and analysis of GWAS. This chapter focuses on some of the basic issues of multistage sampling design as they have been developed for this purpose, and some of the associated analysis issues.

Keywords: genome-wide association studies; study design; methodology

Chapter.  14204 words. 

Subjects: Public Health and Epidemiology

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