Chapter

The challenge of assessing complex gene– environment and gene–gene interactions

Peter Kraft and David J. Hunter

in Human Genome Epidemiology, 2nd Edition

Published in print December 2009 | ISBN: 9780195398441
Published online May 2010 | e-ISBN: 9780199776023 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195398441.003.0009
 							The challenge of assessing complex gene– environment and gene–gene interactions

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This chapter discusses the study of gene-environment and gene-gene interactions in genetic epidemiology. It starts with a review of the definition of statistical gene-environment interaction, which is what is typically measured and reported in genetic association studies, and contrasts this with specific theoretical and general intuitive models for biologic interaction. It then describes how these concepts can be extended to the study of gene-gene interactions, and reviews available study designs, with particular emphasis on estimating joint gene-environment and gene-gene effects.

Keywords: gene-environment interactions; gene-gene interactions; genetic epidemiology

Chapter.  10554 words.  Illustrated.

Subjects: Public Health and Epidemiology

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