Chapter

Coronary heart disease

Adam S. Butterworth, Julian P. T. Higgins, Nadeem Sarwar and John Danesh

in Human Genome Epidemiology, 2nd Edition

Published in print December 2009 | ISBN: 9780195398441
Published online May 2010 | e-ISBN: 9780199776023 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195398441.003.0019
 							Coronary heart disease

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Coronary heart disease (CHD) — which includes myocardial infarction, angina pectoris, and stenosis of the coronary arteries — is the leading cause of death worldwide, with over 7 million deaths per year. The tendency for CHD to cluster in families suggests that genetic variation, either directly or through modulation of known or as yet unidentified risk factors, importantly influences CHD risk. This chapter provides a critical and quantitative review of the current state of evidence regarding potential genetic susceptibility loci and CHD. It reviews published quantitative reviews of candidate gene polymorphisms and published GWAS addressing CHD.

Keywords: genetic variants; genetic variations; human disease; genome-wide studies; coronary heart disease; risk factors

Chapter.  8311 words.  Illustrated.

Subjects: Public Health and Epidemiology

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