Chapter

The role of epidemiology in assessing the potential clinical impact of pharmacogenomics

David L. Veenstra

in Human Genome Epidemiology, 2nd Edition

Published in print December 2009 | ISBN: 9780195398441
Published online May 2010 | e-ISBN: 9780199776023 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780195398441.003.0027
 							The role of epidemiology in assessing the potential clinical impact of pharmacogenomics

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A promising area of genomics is the use of information about genetic variation to guide drug therapy, a field known as pharmacogenomics. Pharmacogenomic applications can be broadly categorized into (a) those related to variation in drug metabolism and disposition genes, which affect the levels of active drug or metabolites in the body and thus both effectiveness and side effects; and (b) those related to variation in genes for drug targets, which primarily influence the effectiveness of a drug. These categories can be applied to both inherited and acquired variation. This chapter discusses the role of epidemiology in assessing pharmacogenomic associations, as well as approaches utilizing epidemiologic data to quantify the potential benefits and harms of pharmacogenomic tests in clinical use.

Keywords: pharmacogenomics; epidemiological data; genetic information; genetic variation; drug therapy

Chapter.  7509 words.  Illustrated.

Subjects: Public Health and Epidemiology

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