A promising area of genomics is the use of information about genetic variation to guide drug therapy, a field known as pharmacogenomics. Pharmacogenomic applications can be broadly categorized into (a) those related to variation in drug metabolism and disposition genes, which affect the levels of active drug or metabolites in the body and thus both effectiveness and side effects; and (b) those related to variation in genes for drug targets, which primarily influence the effectiveness of a drug. These categories can be applied to both inherited and acquired variation. This chapter discusses the role of epidemiology in assessing pharmacogenomic associations, as well as approaches utilizing epidemiologic data to quantify the potential benefits and harms of pharmacogenomic tests in clinical use.
Keywords: pharmacogenomics; epidemiological data; genetic information; genetic variation; drug therapy
Chapter. 7509 words. Illustrated.
Subjects: Public Health and Epidemiology
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