Book

Macromolecular Crystallography

Edited by Mark R. Sanderson and Jane V. Skelly

Published in print August 2007 | ISBN: 9780198520979
Published online September 2007 | e-ISBN: 9780191706295 | DOI: https://dx.doi.org/10.1093/acprof:oso/9780198520979.001.0001

Series: International Union of Crystallography Monographs on Crystallography

Macromolecular Crystallography

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Macromolecular crystallography is the study of macromolecules (proteins and nucleic acids) using X-ray crystallographic techniques in order to determine their molecular structure. The knowledge of accurate molecular structures is a pre-requisite for rational drug design, and for structure-based function studies to aid the development of effective therapeutic agents and drugs. The successful determination of the complete genome (genetic sequence) of several species (including humans) has recently directed scientific attention towards identifying the structure and function of the complete complement of proteins that make up that species; a new and rapidly growing field of study called ‘structural genomics’. There are now several important and well-funded global initiatives in operation to identify all of the proteins of key model species. One of the main requirements for these initiatives is a high-throughput crystallization facility to speed-up the protein identification process. The extent to which these technologies have advanced calls for an updated review of current crystallographic theory and practice. This book features the latest conventional and high-throughput methods, and includes contributions from a team of internationally recognized leaders and experts.

Keywords: macromolecules; proteins; nucleic acids; X-ray; crystallographic techniques; molecular structure; rational drug design; structure-based function studies; therapeutic agents

Book.  304 pages.  Illustrated.

Subjects: Biochemistry

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Table of Contents

First analysis of macromolecular crystals in Macromolecular Crystallography

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In-house macromolecular data collection in Macromolecular Crystallography

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MAD phasing in Macromolecular Crystallography

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Phase refinement through density modification in Macromolecular Crystallography

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